The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate.

AICAR significantly reduced basal levels of pMLC and there was also a trend for a reduction in pMLC levels in cells subsequently treated with CA4P, compared to cells treated in the absence of AICAR; however, the data did not reach statistical significance (Fig. 7a,b ).

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