Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in the Brain and Relevance for Neuropsychiatric Disorders.

Front Neurosci · 2020 · PMC7303295 · PMID 32595449

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nominally significantno p-value reported

Interestingly, a Mendelian randomization study of the PCSK9 LOF variant rs11591147 (R46L, G/T) in 337,536 individuals from the UK Biobank found the T allele was protective against ischemic stroke in the hypothesis-driven set and a nominally significant association with stroke in the full data set ( Rao et al., 2018 ).

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