Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate.

Pharmacodynamic Results In the case of homozygotes AA (80 G>A gene SLC19A1 polymorphism), a statistical trend for higher incidence of transaminase elevation was observed ( P = 0.037 without correction for multiple comparisons).

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35.9 or 37.9 μM) concentrations were observed for homozygotes 3R/3R for tandem repeats of the TS gene however the difference did not reach statistical significance.

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