Prognostic value of the Residual Cancer Burden index according to breast cancer subtype: Validation on a cohort of BC patients treated by neoadjuvant chemotherapy.

- The lack of statistical power of the pCR and RCB-I luminal BC subgroups was mentioned in the discussion, and new analyses were performed pooling together pCR and RCB-I luminal BC subgroups to address this issue (with an almost significant p-value of 0.069). - We also inserted a paragraph describing the meta-analysis of more than 5000 individuals RCB data with long-term follow up which was recently presented by Symmans and colleagues. - Analyses were reconducted only taking into account the subset of patients whose LVI status had bee

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The prognosis impact of the RCB index was significant in TNBC and HER2 -positive BCs, but not in luminal BC ( Fig 4B–4D and S1-S3 Tables in S1 File ) ( P interaction = 0.05, though the interaction test failed to reach statistical significance after multivariate analysis ( P interaction = 0.057)).

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