ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications.

Correlation analysis with relevant data from an external large study, i.e., DEMETER data 15 of RNAi screening showed moderate level correlation but with highly statistical significance for the data of a total of 460 cell lines shared between this dataset and ours (Supplementary Figure 3D ), although the CERES scores 16 of CRISPR screening showed only modest correlation with marginal significance (Supplementary Figure 3E ).

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We wanted to assess whether the trends observed in the colon and pancreas were consistent even though they did not reach statistical significance for pathway level enrichment.

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