Although not found to be statistically significant, neutralization of IFN-γ showed a trend towards increased CFUs vs. control mice at later time points, allowing fungal persistence up to 28 days after infection.
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Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis.
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