48 An initial study of 8100 genes in 20 MPNSTs found no significant differences in expression profile based on NF1 status (10 NF1-related, 10 sporadic), although 6 genes showed a trend near significance, 3 genes were related to whether tumors were peripheral (on a limb) versus central (trunk/neck/head), and metastasis moderately correlated with expression of 12 genes. 49 The authors then examined 22 additional MPNSTs, and found a significant signature that differentiated 9 MPNSTs (8 NF1, 1 sporadic) from the others, characterized by higher expression of neuroglial and Schwann cell differentiation genes (e.g.
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