Actinic keratosis and surrounding skin exhibit changes in corneocyte surface topography and decreased levels of filaggrin degradation products.

Exp Dermatol · 2020 · PMC7317372 · PMID 32112584

Europe PMC DOI

hedged sentences

0.1000

closest p · 2.0× alpha

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boldest claim

The sentences

borderline significantP = .1so close (0.05 < p ≤ 0.1)

A significant difference in DTI between the control retroauricular skin site (D) was found for the visible AK (A), the adjacent skin site (B) and borderline significant ( P = .1) for the skin site at 5 cm from AK (C) (Figure 3C and D ).

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did not reach statistical significanceP = .1so close (0.05 < p ≤ 0.1)

The NMF levels on the AK lesion were lower than those on the control retroauricular skin, although the difference between these sites did not reach statistical significance ( P = .1). 4 CONCLUSIONS The findings of this explorative study show that AFM is a suitable technique to detect and quantify alterations in the corneocyte topography, not only in the AK lesions, but also in the adjacent skin areas without visible changes.

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