Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional mitochondria.

When the control DA neurons were co-cultured with astrocytes plated on 1.0 μM filters containing transwells, the levels of neuronal ATP were elevated (by ~ 43%) but did not reach statistical significance (Fig. 4 b), indicating that some degree of mitochondria transfer may take place under healthy conditions too.

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