Interestingly, heterozygous ( HET ) embryos (lacking only one Nr2f1 allele, hence more similar to BBSOAS patients) already showed a trend in increasing progenitor abundance during neocortical development (Fig EV3 A–F).
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NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients.
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