Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.

Haematologica · 2020 · PMC7327642 · PMID 31582544

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a clear trendno p-value reported

As expected, HS5 cells show a clear trend of protection of HMCL from apoptosis induced by Bor (15% in OPM2 and 26% in U266), Melph (20% in OPM2 and 11% in U266), and Len (14% in OPM2) ( Figure 3B and C ), although the statistical significance was reached only in the case of OPM2 treated with Bor.

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