3 Results 3.1 Effects of aircraft noise and ATII treatment on blood pressure Using tail cuff plethysmography, we observed a significantly higher systolic blood pressure in the mice that were exposed to both ATII and noise as compared to the ATII-only group and a borderline significant increase (p = 0.067) as compared to the noise-only group ( Fig. 1 A).
DHE staining showed increased oxidative stress in the endothelial cell layer of all treatment groups with a significant difference between ATII and ATII + Noise as well as borderline significance between Noise and ATII + Noise ( Fig. 3 C).
S4 , there was a clear trend for downregulation of proteins that account for structural processes, calcium handling and antioxidant defense, mostly in the heart of ATII exposed mice: sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA2a, −60%), mitochondrial manganese-superoxide dismutase (MnSOD, −45%), phospho-connexin 43 (pS325/328/330-Cx43, -20%) and total connexin 43 (Cx43, -30%).