Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development.

Development · 2020 · PMC7328009 · PMID 32467237

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dnMAML thymi showed a trend towards higher proportions of CD4 − CD8 − double-negative (DN) and CD8 + single-positive (SP) thymocytes, and lower proportions of CD4 + CD8 + double-positive (DP) thymocytes, consistent with the changes in Notch ligand expression observed in fetal RBPJ cKO thymi (see below; Table S5 , Fig.

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