Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients.

Firstly, in the exploratory MARS cohort 4 out of the 16 candidate genes (from 18 features), showed significantly different expressions ( p ≤ 0.05) between the response groups at least under one of the incubation conditions: glutamate decarboxylase 1 ( GAD1 ), FYN binding protein ( FYB ), receptor activity modifying protein 1 ( RAMP1 ), TBC1 domain family member 9 ( TBC1D9 ), while other four genes showed a trend ( p ≤ 0.2): paired like homeodomain 1 ( PITX1 ), nuclear factor I B ( NFIB ), glutamate ionotropic receptor NMDA type subunit 2A ( GRIN2A ), aminoadipate aminotransferase ( AADAT ) (Fig. 2b, c , Supplementary Table 8 ).

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