Lower T Regulatory and Th17 Cell Populations Predicted by RT-PCR-Amplified <i>FOXP3</i> and <i>ROR</i>γ<i>t</i> Genes Are Not Rare in Patients With Primary Immunodeficiency Diseases.

In contrast to the healthy controls who showed a trend of age-dependent Treg cell subpopulations ( Figure 4A ) ( 52 , 53 ), the majority of the studied PIDs patients had a more age-independent predicted Treg cell subpopulation ( Figure 4C ), but over 85% (78/91) maintained relatively lower Th17 populations that inhibited human B cell survival and activation of antibody-secreting plasma cells ( 54 ).

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