Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review.

Of note, vancomycin was studied in six separate studies, only one of which included a non-ECMO comparator group ( 22 ) while the remaining five did not ( 20 , 21 , 23 , 24 , 50 ) Although a trend was observed toward smaller V d of vancomycin relative to non-ECMO controls, the difference did not reach statistical significance in the study by Buck ( 22 ) However, when the V d values were compared against historical controls, increased V d was observed compared to pediatric patients not on ECMO ( 20 , 21 , 23 , 24 , 50 ).

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