Estradiol Increases Microglial Response to Lipopolysaccharide in the Ventromedial Hypothalamus during the Peripubertal Sensitive Period in Female Mice.

While LPS increased IL-6 levels in ovariectomized oil-controls and estradiol-treated mice 6 and 24 h post-LPS administration, the effect of LPS on IL-6 levels 6 h following LPS administration to ovariectomized, estradiol-treated mice did not reach statistical significance ( Fig. 3 E , F ).

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