Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.

Proc Natl Acad Sci U S A · 2020 · PMC7334536 · PMID 32527859

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quite significantno p-value reported

However, even the small differences in the slope and intercept in a linear fit to their data are quite significant because of the enormous sensitivity of the delay time ( t d ) to hemoglobin concentration [1/ t d ∼ (3.61/3.02) 30 = 200, see below].

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