While the V / F from the non-compartmental analysis, and the rate of absorption ( k a ), central and peripheral volumes ( V 2 / F and V 3 / F ) from compartmental analyses were generally comparable from low to high doses, there were a strong trend towards decreasing clearance (both distribution and elimination) with increasing doses.
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Pharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies.
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