Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease.

Previously, we observed a trend of toward a positive correlation between the number of CUG repeat RNA foci in endothelial cells of surgical samples and triplet repeat allele but it did not reach statistical significance ( 26 ).

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They are useful for visualizing patterns of changes and identifying ‘outlier’ genes that combine highly significant changes in gene expression with higher fold changes.

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