Nature and Nurture: Effects of Affective Temperaments on Depressive Symptoms Are Markedly Modified by Stress Exposure.

In the group with moderate RLE exposure after correction for multiple testing, the effect of depressive (β = 0.265, p = 0.001, q = 0.003), cyclothymic (β = 0.283, p < 0.001, q < 0.001) and hyperthymic (β = −0.132, p = 0.033, q = 0.046) affective temperaments on BSI depression was significant, the effect of anxious temperament was nominally significant but did not survive correction for multiple testing (β = 0.171, p = 0.030, q = 0.053), and irritable temperament had no significant effect (β = 0.104, p = 0.121, q = 0.141) ( Table 5 ).

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However, in case of moderate recent stress exposure, only the effect of depressive and cyclothymic temperaments remained significant on current depression severity while the effects of hyperthymic temperament was marginally significant, which suggests that in case of moderately severe life events, low mood, and mood lability will be the relevant contributors to depressive symptoms.

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