A clear trend for shorter OS was also seen when we considered the increase T1–T2 (Supplementary Figs. 3 and 5g ) and became statistically significant when we evaluated the impact of the presence of KRAS mutation at T3 and its increase T1–T3 ( p = 0.0031 and p = 0.018; Supplementary Figs. 3 and 5f, h ).
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Early assessment of KRAS mutation in cfDNA correlates with risk of progression and death in advanced non-small-cell lung cancer.
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