Similar associations were observed at baseline CTC1 and post-treatment CTC4 by Kaplan–Meier PFS analysis (log rank test, CTC1, p = 0.030 and CTC4, p = 0.039), whereas CTC2, CTC3, and blood mutation load at CTC4 did not reach statistical significance ( p = 0.21, 0.16, 0.17, respectively) (Fig. 4 b (i–v)).
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Clinical utility of serial analysis of circulating tumour cells for detection of minimal residual disease of metastatic nasopharyngeal carcinoma.
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4 b (viii)) were significantly longer than that of the high-risk group, although only a trend with marginal significance was observed for intermediate-risk vs high-risk groups for PFS and CTC1/CTC4.