Pyrosequencing detected very small methylation changes in the Tet1 promoter, with NNK treatment causing a 0.3%, 0%, 0.1%, and 1.3% increase at CpGs 1, 2, 3, 4 and 1.2% decrease at CpG 5, which did not reach statistical significance (Supplementary Fig.
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Inhalation exposure to cigarette smoke and inflammatory agents induces epigenetic changes in the lung.
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