Clathrin inhibition also decreased ErbB2 phosphorylation in HepG2 cells, but the effects were less marked and failed to reach statistical significance.
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Regulation of the EGFR/ErbB signalling by clathrin in response to various ligands in hepatocellular carcinoma cell lines.
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Transfection of siCHC in HepG2 was associated with a twofold to threefold highly significant increase in EGFR expression, whatever cells were stimulated with any of the ErbB ligands or not, indicating that although inhibition of CHC expression was only partial, it was sufficient to modulate EGFR expression (Figure 3A and Figure S1 ).