Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective.

Interestingly, a notable trend for an interaction between Sex and Drinking Group was detected for the adult-onset mice tested in early withdrawal ( Figure 11 B) ( F (1,51) = 3.34, p = 0.07).

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This trend reflected more marble-burying in male binge-drinkers versus their water controls ( t (19) = 3.61, p = 0.002), while no alcohol-water difference was apparent in the females tested at this time ( t -test, p = 0.57). 3.4.

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Deconstruction of this interaction did not reveal any significant group differences; however, a statistical trend in the latency to enter the light side was observed for female mice in that female binge-drinkers exhibited a shorter latency to enter the light side, compared with their water-drinking counterparts ( t (26) = 1.97, p = 0.06).

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