Several subgroup analyses of studies including adult and elderly patients showed a trend to a prolonged progression-free survival (PFS) and an increased period of steroid independence in elderly persons and perhaps also on overall survival (OS) while a randomized trial of first-line use of bevacizumab combined to hypofractionated radiotherapy failed to show a survival advantage [ 21 ].
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Guiding Treatment Choices for Elderly Patients with Glioblastoma by a Comprehensive Geriatric Assessment.
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