Subtype was significantly associated with the presence of distant metastasis at diagnosis and showed a trend towards significant association with lymphovascular invasion (LVI) at diagnosis, with a higher proportion of cases with LVI and distant metastasis for subtype A compared with B.
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<i>PDX1</i> DNA Methylation Distinguishes Two Subtypes of Pancreatic Neuroendocrine Neoplasms with a Different Prognosis.
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The sentences
The presence of distant metastasis at diagnosis and recurrence after surgery are significantly more common for subtype A PNENs, and a trend towards significance was observed for LVI at diagnosis.