When the individual Δanisotropy time trace for each irradiated cell is examined closely (Supplemental Figure 5), 21 out of 27 cells show positive increase in delta anisotropy and only 6 out of 27 cells show an overall negative trend over the 2 h after damage, whereas in control cells, 7 out of 13 cells show a positive trend and 6 out of 13 cells show a negative trend.
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Monitoring global changes in chromatin compaction states upon localized DNA damage with tools of fluorescence anisotropy.
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