Benefits of High-Flow Nasal Cannula Therapy for Acute Pulmonary Edema in Patients with Heart Failure in the Emergency Department: A Prospective Multi-Center Randomized Controlled Trial.

After adjusting the baseline value, lactate levels revealed a borderline significant trend for the p -value, and the statistical significances of differences in other parameters were similar to those identified on post hoc analysis ( Table 4 ).

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All statistical tests were two-tailed, and p < 0.05 was considered indicative of statistical significance; moreover, 0.05 ≤ p < 0.1 was considered to represent a trend toward significance to increase the sensitivity for the detection of potential selection biases. 3.

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