Intracranial hemodynamic relationships in patients with cerebral small vessel disease.

Lower white matter CVR with increasing age did not reach statistical significance ( p = 0.09).

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A trend for increasing age to be associated with lower CVR narrowly failed to reach significance in our study, but age was associated with lower CVR in several other studies. 40 , 41 , 44 , 45 The lack of a definite age-CVR relationship in the present study may reflect poorer brain vascular health in the younger compared with the older patients with stroke because patients who experience a stroke aged in their 40s or 50s may have worse vascular health than those who do not experience stroke until their ninth decade.

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