Reply to Gautret et al: hydroxychloroquine sulfate and azithromycin for COVID-19: what is the evidence and what are the risks?

The fact that the difference in age between intervention and control populations did not reach statistical significance reflects the small study population – markedly smaller than the 48 individuals proposed in sample size calculations – and does not mean that age may not have been a relevant determinant of the kinetics of viremia.

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