Chronic migraine long-term regular treatment with onabotulinumtoxinA: a retrospective real-life observational study up to 4 years of therapy.

Alongside consumption reduction, analgesics latency time (hours) significantly shrunk from a mean of 5.8 ± 0.9 at T0 to 2.7 ± 1.8 at T6 and 2.0 ± 1.6 at T12 (T6 vs T0 and at T12 vs T6 p < 0.001), revealing a significant trend over the entire period under consideration ( p for trend < 0.001).

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