Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression.

LPS-induced inflammation The overall LPS-induced inflammation index ( β = 0.036; p = 0.014) and the LPS-induced inflammation index-2 ( β = 0.056, p < 0.001) were significantly related to the IDS score averaged over 30 items, and the LPS-induced inflammation index-1 indicated a relationship that approached significance ( β = 0.026; p = 0.072).

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By conducting regression analysis for each individual symptom separately, we demonstrated that significant associations between inflammatory markers and the course of a particular individual symptom was more than twice as likely to be significant when that symptom was related to sickness behavior compared with non-sickness-related behavior.

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