Immunopathology of SARS-CoV-2 Infection: Immune Cells and Mediators, Prognostic Factors, and Immune-Therapeutic Implications.

Int J Mol Sci · 2020 · PMC7370171 · PMID 32640747

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did not reach statistical significanceno p-value reported

A decrease in naïve (CD45RA+CD3+CD4+CD25+ CD127low+) and induced (CD45RO+CD3+CD4+CD25+CD127low+) regulatory T cells was also evident in critical patients, although the data did not reach statistical significance in comparison to other groups of patients [ 10 ].

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an increasing trendno p-value reported

Remarkably, TP53, an essential gene in the process of programmed cell death, exhibits an increasing trend, suggesting that peripheral blood mononuclear cells’ decrease may be due to an increase in programmed cell death [ 16 ]. 2.2.

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a decreasing trendno p-value reported

The increase in WBCs was mainly caused by neutrophils, while a decreasing trend has been observed for lymphocytes, eosinophils and monocytes.

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