Intranasal challenge with LPS resulted in a highly significant 14.5-fold increase in pulmonary vascular permeability (Fig. 2a ).
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Vascular endothelial growth factor contributes to lung vascular hyperpermeability in sepsis-associated acute lung injury.
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The mRNA level of VEGFR1 showed a trend toward increasing throughout 3–24 h observation period (Fig. 3b ).