Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth.

Cathelicidin Overall, after adjustment, compared to women who delivered at term, CVF cathelicidin concentration was numerically 32% higher in high-risk women who delivered prematurely < 37 weeks (p = 0.04), and 17% higher in women who delivered < 34 weeks though this did not reach statistical significance (p = 0.38) (Table 5 ).

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After exclusion of samples taken after clinical intervention for cervical shortening had been initiated, unadjusted elafin concentrations measured at 10–13 +6 weeks’ gestation were higher overall in women who delivered prior to 34 weeks’ gestation (n = 390, ratio 1.76, 1.00 to 3.10, p = 0.05) though this did not quite reach statistical significance, nor after adjustment (n = 387, 1.59, 0.93–2.80).

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