Short-and long-term administration of imeglimin counters cardiorenal dysfunction in a rat model of metabolic syndrome.

Treatment with imeglimin for 90 days significantly reduced interstitial fibrosis; while the glomerular injury score and interstitial inflammation were also reduced, the reduction did not reach statistical significance (Table 3 ). 3.12 Exercise tolerance Maximal running distance was 438 ± 2 m in 24‐week‐old lean animals (n = 4) and was reduced to 123 ± 13 m in 24‐week‐old untreated Zucker animals (n = 7). 90 days of treatment with imeglimin resulted in an increase of maximal running distance to 161 ± 19 m (n = 5), without reaching statistical significance. 3.13 Acute effects of imeglimin As soon as 1 hour after imeglimin administration, plasma fasting glucose was not modified.

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