Aging affects sex- and organ-specific trace element profiles in mice.

Only Fe and Cu concentrations showed a trend toward upregulation of Fe and downregulation of Cu in old mice ( Figure 2E , 2F ), which was significant when considering all mice irrespective of sex ( Supplementary Table 2 ).

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Whereas the expression levels of these TE-related genes did not strongly correlate with TE concentrations in serum, liver, or duodenum, highly significant correlations between the individual transporters were identified ( Supplementary Figure 3 ).

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