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Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants.

Sci Rep · 2020 · PMC7378054 · PMID 32704023

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an increasing trendno p-value reported
According to data from the National Institute of Child Health and Human Development, during the years 2003 to 2007, the incidence of BPD in infants less than 29 weeks gestational age was 42% 6 with an increasing trend over the past 10 years 7 .

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In contrast, whereas the survival of normoxia treated rats was similar in both groups, (94% vs 94%, normoxia-PL vs normoxia-Klotho, N = 16/group), there was a trend for improved survival in the Klotho supplemented hyperoxia-exposed rats, which did not reach statistical significance (44% vs 69%; hyperoxia-PL vs hyperoxia-Klotho, N = 7–11/group).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.