Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice.

G007-LK treatment alleviated dyslipidemia of the db/db mice by lowering serum low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and total cholesterol (Table 1 ), whereas with triglycerides, glycerol, and nonesterified fatty acids the difference between treated and nontreated groups (Table 1 ) did not reach statistical significance.

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