An assessment of the centrally acting muscle relaxant tolperisone on driving ability and cognitive effects compared to placebo and cyclobenzaprine.

Reaction time variability (ie SD of reaction time) on the SDC test was not significantly impacted for tolperisone compared to placebo, but for cyclobenzaprine, it approached significance on day 1 and was significantly higher on day 2; this finding indicated more inconsistency in response speed ( P < .05). 3.5 Self‐reported measures Self‐reported sleepiness, self‐reported motivation and self‐appraised driving performance showed no significant effects for tolperisone compared to placebo, while subjects reported increased sleepiness (day 1), decreased motivation (days 1 and 2) and worse performance on the driving task (days 1 and 2) with cyclobenzaprine (Table 5 ).

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