Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.

Glucose and insulin excursions on oral glucose tolerance testing showed a trend towards an increase in male Pik3r1 WT/Y657 ∗ mice ( Figure 3 B,C), but were increased in female mice ( Figure S4A,B ), while the hypoglycaemic response to insulin was attenuated in both sexes ( Figures 3 D and S4C ).

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