STRING data mining of GWAS data in canine hereditary pigment-associated deafness.

2 highlight gene clusters with highly significant associations.

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An initial candidate list of 400 genes was assembled from (1) genes located within 500 kb of single nucleotide polymorphisms (SNPs) from our previous GWAS that had approached significance (235 genes), (2) pigmentation genes (31 genes) ( UniProt Consortium, 2019 ), (3) genes identified in humans as responsible for non-syndromic autosomal recessive and dominant deafness (113 genes) ( Van Camp and Smith, 2020 ), and (4) genes identified from proteomic studies of mouse cochlear inner hair cells and rat stria vascularis tissues that were also located near our GWAS SNPs (21 genes) ( Hickox et al., 2017 ; Uetsuka et al., 2015 ).

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