Barely Significant
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A multicenter, randomized study to select the minimum effective dose of estetrol (E4) in postmenopausal women (E4Relief): part 1. Vasomotor symptoms and overall safety.

Menopause · 2020 · PMC7386865 · PMID 32379217

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nearly significantno p-value reported
Similarly, nearly significant effects were also observed at W4.

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