Postmarketing safety surveillance data reveals antidepressant effects of botulinum toxin across various indications and injection sites.

Interestingly there was also a decrease in depression reports where BoNT was injected into the detrusor muscle in the neurological and urinary bladder disorders cohort, but the reduced ROR value did not reach statistical significance (0.77 [0.43, 1.43]) (Fig. 3 ).

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