The impact of antidepressants on depressive symptom severity, quality of life, morbidity, and mortality in heart failure: a systematic review.

16 Citalopram showed no difference in severity but showed a trend toward reduction on MADRS ( p =0.082). 15 Nortriptyline ( p <0.001) and nefazodone ( p <0.001) were also found to reduce depression scores. 32 , 29 Studies looking at the use of other antidepressants (SSRIs, TCA, NDRIs, SNRIs, buproprion, and fluoxetine) were not able to draw conclusions about causation in relation to depression severity. 33 – 35 What is the impact of antidepressant medications on health-related quality of life?

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However, there was a trend toward significance on depression severity assessed on the Montgomery–Åsberg Depression Rating Scale (MADRS) ( p =0.082), with the citalopram group showing a bigger reduction in MADRS. 15 O’Connor et al., who conducted a larger study ( n =469) on 12-week sertraline treatment also found no difference compared to placeb

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