Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography.

However, after caffeine, all 3 layers of the retina showed a trend of delayed rise in AFI during light adaptation, with the AFI peaking in the control condition at 5 minutes and in the caffeine condition at 15 minutes ( Fig. 3 ).

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In addition, despite an overall trend of delay in rise of AFI in ambient light, we did not find significant differences in AFI, a surrogate of flow, between the caffeine and control groups in the dark.

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