Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma.

Regarding the secreted proteins fibronectin and Col1, freshly isolated monocytes expressed no fibronectin or Col1, and cells cultured in vitro started to express fibronectin (Figure S2C) but not Col1; however, the effect of H 2 O 2 on fibronectin expression varied among cells from different donors, and the difference in mRNA (Figure 2I ) or protein (Figures 2E, 2H , and 2J ) levels did not reach statistical significance.

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