Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome.

Transcription factors specifying granulomonocytic commitment and differentiation, such as SPI1 and CEBPA , were also consistently more highly expressed in CMML-1 versus CMML-2 stem cells, but did not reach statistical significance possibly due to small sample size ( Fig. 5 C).

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We observed a highly significant down-regulation of a normal Lin − CD34 + CD38 − HSC gene set in CMML versus normal Lin − CD34 + CD38 − HSCs ( Fig. 2 A) and a highly significant up-regulation of genes selectively expressed in oligopotent Lin − CD34 + CD38 + neutrophil-primed or monocyte/dendritic cell-primed progenitors ( Fig. 2 B).

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